Impact of a synchronous prophylactic treatment of the anterior accessory saphenous vein on the recurrent varicose vein rate in patients undergoing thermal ablation of an insufficient great saphenous vein (SYNCHRONOUS-Study): study protocol for a prospective, multicentre, controlled observational study

Introduction Chronic venous insufficiency caused by varicose veins is a common disorder.1 Approximately, 50% of the…

Optimising transitions of care for acute kidney injury survivors: protocol for a mixed-methods study of nephrologist and primary care provider recommendations

Strengths and limitations of this study The sampling frame for both the quantitative and qualitative strands…

Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study–INTERACT MESO

Strengths and limitations of this study The INTERACT MESO trial is the first trial that investigates…

Understanding personality pathology in a clinical sample of youth: study protocol for the longitudinal research project ‘APOLO

Introduction Recent developments in the field of personality psychology (ie, scientific research on personality structure) and…

ezPreemie study protocol: a randomised controlled factorial trial testing web-based parent training and coaching with parents of children born very preterm

Introduction Given remarkable medical progress, the survival rate of very preterm (VPT) infants (gestational age <32…

Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational study

Introduction Lung cancer is the leading cause of cancer-related deaths in the USA and worldwide,1 largely…

Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study

Strengths and limitations of this study This is the first study for estimating the simultaneous effect…

Effect of intramuscular midazolam premedication on patient satisfaction in women undergoing general anaesthesia: a randomised control trial

Strengths and limitations of this study This study prospectively investigated the role of midazolam premedication in…

More than just staffing? Assessing evidence on the complex interplay among nurse staffing, other features of organisational context and resident outcomes in long-term care: a systematic review protocol

Introduction Demographic changes such as decreasing fertility and population ageing have increased the pressure on residential…

Outcomes of psychiatric interviews and self-rated symptom scales in people on sick leave for common mental disorders: an observational study

Strengths and limitations of this study The use of structured psychiatric assessments is a strength of…